Oral Fluconazole May Lead To Loss Of Pregnancy

Pregnant women are at a higher risk of developing the yeast infection vaginal
candidiasis. This is due to an increased secretion of sex hormones.


Although oral fluconazoles are often used, topical azole antifungals are the first-line
treatment for pregnant women.

Researchers from the Statens Serum Institut in Copenhagen, Denmark evaluated the association between oral fluconazole exposure during pregnancy and the risk
of spontaneous abortion and stillbirth.

In a nationwide cohort study, the team studied 1,405,663 pregnancies from 1997-2013 in Denmark.

Results showed a significantly increased risk of spontaneous abortion associated with fluconazole exposure but the association between fluconazole exposure and stillbirth was not significant.